chromosomal : Dictionary / Wörterbuch (BEOLINGUS, TU Chemnitz)

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(1979), Chromosomal Aberration Tests on 29 Chemicals Combined with S9 Mix In Vitro, Mutation Res., 66, 277-290. [EU]

Mutation Res., 66, p. 277-290.

Ashby, J. et al., (eds) Elsevier Science Publishers, Amsterdam-New York-Oxford. [EU]

The In Vitro Chromosomal Aberration Test Using Chinese Hamster Lung (CHL) Fibroblast Cells in Culture.

Auslösung von Chromosomen-Mutationen in Säugetierzellen und [EU]

Induction of chromosomal aberrations in mammalian cells; and

Dabei ist zwischen strukturellen Chromosomentyp- und Chromatidentypaberrationen zu unterscheiden. [EU]

The purpose of the in vitro chromosomal aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian cells (1)(2)(3).

Da schließlich die Mikrokerne von verzögert transportierten Chromosomen herrühren können, besteht die Möglichkeit, Aneuploidie induzierende Agenzien nachzuweisen, deren Untersuchung in konventionellen Chromosomenaberrationstests nur schwer möglich ist, z. B. OECD-Prüfrichtlinie 473 (Kapitel B.10 dieses Anhangs) (17). [EU]

Finally, as micronuclei may arise from lagging chromosomes, there is the potential to detect aneuploidy-inducing agents that are difficult to study in conventional chromosomal aberration tests, e.g. OECD Test Guideline 473 (Chapter B.10 of this Annex) (17).

Der Begriff Mutation gilt sowohl für vererbbare genetische Veränderungen, die sich im Phänotyp ausdrücken können, als auch für die zugrunde liegenden DNA-Veränderungen, sofern sie bekannt sind (einschließlich spezifischer Basenpaar-Veränderungen und chromosomaler Translokationen). [EU]

The term 'mutation' applies both to heritable genetic changes that may be manifested at the phenotypic level and to the underlying DNA modifications when known (including specific base pair changes and chromosomal translocations).

Die Verfahren sollten einer der folgenden OECD-Leitlinien sowie sonstigen einschlägigen OECD-Leitlinien für In-vitro- und In-vivo-Tests entsprechen: 471 (Salmonella typhimurium Reverse Mutation Test), 472 (Escherichia coli Reverse Mutation Test), 473 (In vitro Mammalian Chromosome Aberration Test), 474 (Mammalian Erythrocyte Micronucleus Test), 475 (Mammalian Bone Marrow Chromosome Aberration Test), 476 (In vitro Mammalian Cell Gene Mutation Test) oder 482 (Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro). [EU]

Protocols should be in line with OECD Guideline 471 (Salmonella typhimurium Reverse Mutation Test), 472 (Escherichia coli Reverse Mutation Test), 473 (in vitro Mammalian Chromosomal Aberration Test), 474 (Mammalian Erythrocyte Micronucleus Test), 475 (Mammalian Bone Marrow Chromosomal Aberration Test), 476 (in vitro Mammalian Cell Gene Mutation Test) or 482 (Unscheduled DNA Synthesis in Mammalian Cells in vitro), as well as other relevant OECD Guidelines for in vitro and in vivo assays.

Galloway, S. M., Aardema, M. J., Ishidate, M. Jr., Iven, J. L, Kirkland, D. J., Morita, T., Mosesso, P., Sofuni, T. (1994), Report from Working Group on in In Vitro Tests for Chromosomal Aberrations, Mutation Res., 312, 241-261. [EU]

Galloway, S.M., Aardema, M.J., Ishidate, M.Jr., Ivett, J.L., Kirkland, D.J., Morita, T., Mosesso, P., Sofuni, T., (1994) Report from Working Group on in In Vitro Tests for Chromosomal Aberrations. Mutation Res., 312, p. 241-261.

Heddle, J. A. (1973), A Rapid In Vivo Test for Chromosomal Damage, Mutation Res., 18, 187-190. [EU]

Heddle, J.A., (1973) A Rapid In Vivo Test for Chromosomal Damage, Mutation Res., 18, p. 187-190.

Insbesondere Benomyl, aber auch Thiophanatmethyl, wird zu Carbendazim metabolisiert und alle drei Stoffe verursachen bei In-vivo-Exposition numerische chromosomale Aberrationen (Aneuploidie) bei Säugetierzellen. [EU]

Benomyl in particular, but also thiophanate-methyl, is metabolised to carbendazim and all three substances produce numerical chromosomal aberrations (aneuploidy) in mammalian cells, exposed in vivo.

Insbesondere Benomyl, aber auch Thiophanat-Methyl, wird zu Carbendazim metabolisiert und alle drei Stoffe verursachen bei In-vivo-Exposition numerische Chromosomenaberrationen (Aneuploidie) bei Säugetierzellen. [EU]

Ishidate, M. Jr. and Sofuni, T. (1985), The In Vitro Chromosomal Aberration Test Using Chinese Hamster Lung (CHL) Fibroblast Cells in Culture, in: Progress in Mutation Research, Vol. 5. [EU]

Ishidate, M. Jr. and Sofuni, T., (1985).

Klastogen Substanz oder Prozess, die/der strukturelle Chromosomenaberrationen in Zell- oder Organismenpopulationen verursacht. [EU]

Clastogen any substance or process which causes structural chromosomal aberrations in populations of cells or organisms.

MacGregor, J. T., Schlegel, R., Choy, W. [EU]

MacGregor, J.T., Schlegel, R. Choy, W.N., and Wehr, C.M., (1983) Micronuclei in Circulating Erythrocytes: A Rapid Screen for Chromosomal Damage During Routine Toxicity Testing in Mice.

Man geht allgemein davon aus, dass dominante Letalgene auf Chromosomenschäden (strukturelle und numerische Anomalien) zurückgehen. [EU]

It is generally accepted that dominant lethals are due to chromosomal damage (structural and numerical anomalies).

Matsuoka, A., Hayashi, M. and Ishidate, M. Jr. [EU]

Matsuoka, A., Hayashi, M. and Ishidate, M. Jr., (1979) Chromosomal Aberration Tests on 29 Chemicals Combined with S9 Mix In Vitro.

Mikroorganismen-Stämme, die eine Resistenz gegen antimikrobielle Wirkstoffe entwickelt haben, kommen nicht als Futtermittelzusatzstoffe zum Einsatz, es sei denn, es lässt sich nachweisen, dass die Resistenz das Ergebnis einer oder mehrerer Chromosomen-Mutationen und nicht übertragbar ist. [EU]

Strains of micro-organisms carrying an acquired resistance to antimicrobial(s) shall not be used as feed additives, unless it can be demonstrated that resistance is a result of chromosomal mutation(s) and it is not transferable.

N., and Wehr, C. M. (1983), Micronuclei in Circulating Erythrocytes: A Rapid Screen for Chromosomal Damage During Routine Toxicity Testing in Mice, in: Developments in Science and Practice of Toxicology, ed. [EU]

Iin: 'Developments in Science and Practice of Toxicology', Ed. A.W. Hayes, R.C.

Positive Ergebnisse des Mikrokerntests deuten darauf hin, dass die Prüfsubstanz Mikrokerne verursacht, die infolge einer Chromosomenschädigung oder einer Schädigung des mitotischen Apparats in den Erythroblasten der geprüften Spezies entstehen. [EU]

Positive results in the micronucleus test indicate that the substance induces micronuclei which are the result of chromosomal damage or damage to the mitotic apparatus in the erythroblasts of the test species.

Tice, R. R. Hayashi, M., MacGregor, J. T., Anderson, D., Blakey, D. H., Holden, H. E., Kirch-Volders, M., Oleson Jr., F. B., Paccierotti, F., Preston R. J., Romagna F., Shimada, H., Sutou, S. and Vannier, B. (1994), Report from the Working Group on the In Vivo Mammalian Bone Marrow Chromosomal Aberration Test, Mutation Res., 312, 305-312. [EU]

Tice, R.R., Hayashi, M., MacGregor, J.T., Anderson, D., Blakey, D.H., Holden, H.E., Kirsch-Volders, M., Oleson Jr., F.B., Pacchierotti, F., Preston, R.J., Romagna, F., Shimada, H., Sutou, S. and Vannier, B., (1994) Report from the Working Group on the In Vivo Mammalian Bone Marrow Chromosomal Aberration Test. Mutation Res., 312, p. 305-312.

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