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1 error
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3 results for rabbit test
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rabbit
·
test
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German
English
Obwohl
die
Empfindlichkeit
der
validierten
Referenzmethode
für
die
in
Tabelle
1
aufgeführten
20
Referenzsubstanzen
gleich
90
%
ist
,
wird
der
vorgegebene
minimale
Empfindlichkeitswert
,
der
erreicht
werden
muss
,
damit
ein
vergleichbares
oder
modifiziertes
Verfahren
als
valide
angesehen
werden
kann
,
auf
80
%
festgelegt
,
da
sowohl
1-Decanol
(
eine
Grenzchemikalie
)
als
auch
Di-n-propyldisulphid
(
ein
falsch
negatives
Ergebnis
der
VRM
)
als
nicht
reizend
beim
Menschen
bekannt
sind
(
31
) (
32
) (
33
),
obgleich
sie
im
Kaninchen
test
als
Reizstoffe
eingestuft
wurden
. [EU]
Although
the
sensitivity
of
the
VRM
calculated
for
the
20
Reference
Chemicals
listed
in
Table
1
is
equal
to
90
%,
the
defined
minimum
sensitivity
value
required
for
any
similar
or
modified
method
to
be
considered
valid
is
set
at
80
%
since
both
1-decanol
(a
borderline
chemical
)
and
di-n-propyl
disulphide
(a
false
negative
of
the
VRM
)
are
known
to
be
non-irritant
in
humans
(31) (32) (33),
although
being
identified
as
irritants
in
the
rabbit
test
.
PRÜF-
UND
BEWERTUNGSSTRATEGIE:
HAUTREIZUNG/-VERÄTZUNG
[EU]
Perform
validated
and
accepted
in
vitro
or
ex
vivo
test
for
skin
irritation
Irritant
response
Assume
irritancy
in
vivo
.
No
further
test
ing
is
needed
.
↓
;
Validated
in
vitro
or
ex
vivo
test
ing
methods
for
skin
irritation
are
not
yet
available
or
substance
is
not
an
irritant
↓
; 7
Perform
initial
in
vivo
rabbit
test
using
one
animal
Severe
damage
to
skin
Considered
corrosive
.
No
further
test
ing
is
needed
.
↓
;
No
severe
damage
↓
; 8
Perform
confirmatory
test
using
one
or
two
additional
animals
Corrosive
or
irritating
Considered
corrosive
or
irritating
.
No
further
test
ing
is
needed
Not
corrosive
or
irritating
Considered
not
corrosive
or
irritating
.
No
further
test
ing
needed
(1)
can
be
considered
before
Steps
2
and
3.
Zu
beachten
ist
dabei
,
dass
der
In-vivo-
Test
an
Hasen
hinsichtlich
der
hautätzenden
Wirkung
und
Hautreizung
im
Vergleich
zum
Test
mit
menschlichen
Hautstücken
ausgesprochen
konservativ
angelegt
ist
(
15
). [EU]
It
should
be
noted
that
the
in
vivo
rabbit
test
is
highly
conservative
with
respect
to
skin
corrosivity
and
skin
irritation
when
compared
with
the
human
skin
patch
test
(15).
The example sentences [G] were kindly provided by the
Goethe Institute
.
Sentences marked by [EU] derived from
DGT Multilingual Translation Memory
. The European Commission retains ownership of the copyright in the original data.
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