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7
similar
results for binucleated
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German
English
CytoB
ist
das
am
häufigsten
verwendete
Agens
zur
Zytokinese-Blockierung
,
da
es
den
Aktinaufbau
hemmt
und
somit
die
Trennung
der
Tochterzellen
nach
der
Mitose
verhindert
,
was
wiederum
zur
Bildung
zweikerniger
Zellen
führt
(5) (
54
) (
55
). [EU]
CytoB
is
the
agent
that
has
been
most
widely
used
to
block
cytokinesis
because
it
inhibits
actin
assembly
,
and
thus
prevents
separation
of
daughter
cells
after
mitosis
,
leading
to
the
formation
of
binucleated
cells
(5) (54) (55).
Für
jeden
Zelltyp
sollte
das
Labor
die
geeignete
cytoB-Konzentration
festlegen
,
um
in
den
Lösungsmittel-/Vehikelkontrollkulturen
eine
optimale
Frequenz
der
zweikernigen
Zellen
zu
erreichen
. [EU]
The
appropriate
concentration
of
cytoB
should
be
determined
by
the
laboratory
for
each
cell
type
to
achieve
the
optimal
frequency
of
binucleated
cells
in
the
solvent/vehicle
control
cultures
.
In
Kulturen
,
die
mit
cytoB
behandelt
wurden
,
sollten
die
Mikrokernfrequenzen
von
mindestens
2000
zweikernigen
Zellen
pro
Konzentration
(
mindestens
1000
zweikernige
Zellen
pro
Kultur
;
zwei
Kulturen
pro
Konzentration
)
analysiert
werden
. [EU]
In
cytoB-treated
cultures
,
micronucleus
frequencies
should
be
analysed
in
at
least
2000
binucleated
cells
per
concentration
(at
least
1000
binucleated
cells
per
culture
;
two
cultures
per
concentration
).
RI
=
Zahl
der
zweikernigen
Zellen
[EU]
RI
=
No
.
binucleated
cells
Verwendete
Messung
der
Zytotoxizität
, z. B.
CBPI
oder
RI
bei
der
Zytokinese-Block-Methode
;
RICC
,
RPD
oder
PI
,
wenn
keine
Zytokinese-Block-Verfahren
verwendet
werden
;
sonstige
Beobachtungen
bei
Bedarf
, z. B.
Zell-Konfluenz
,
Apoptose
,
Nekrose
,
Metaphasezählung
,
Frequenz
zweikerniger
Zellen
[EU]
Measurement
of
cytotoxicity
used
, e.g.
CBPI
or
RI
in
the
case
of
cytokinesis-block
method
;
RICC
,
RPD
or
PI
when
cytokinesis-block
methods
are
not
used
;
other
observations
when
applicable
, e.g.
cell
confluency
,
apoptosis
,
necrosis
,
metaphase
counting
,
frequency
of
binucleated
cells
Wenn
Einfachkulturen
verwendet
werden
,
sollten
in
einer
solchen
Kultur
mindestens
2000
zweikernige
Zellen
pro
Konzentration
ausgewertet
werden
. [EU]
If
single
cultures
are
used
,
at
least
2000
binucleated
cells
per
concentration
should
be
scored
from
that
culture
.
Zahl
der
zweikernigen
Zellen
[EU]
No
.
binucleated
cells
The example sentences [G] were kindly provided by the
Goethe Institute
.
Sentences marked by [EU] derived from
DGT Multilingual Translation Memory
. The European Commission retains ownership of the copyright in the original data.
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